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Understanding animal behavior: Animal cognitive behavioral tests help researchers gain insight into how animals think, learn, and solve problems. By conducting cognitive behavioral tests, scientists can better understand the cognitive abilities of different animal species and how they compare to humans. Comparative studies: Comparative cognition research is important for understanding the evolution of cognitive…
Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD3 receptor. Visilizumab is a humanized monoclonal antibody. It is being investigated for use as an immunosuppressive drug in patients with ulcerative colitis and Crohn’s disease. Immunogen The details of the immunogen for this antibody are not available. Host Species Mouse Derivation Humanized (from…
Recombinant humanized antibody expressed in CHO binding to human SLAMF7/CD319. Elotuzumab is a humanized monoclonal antibody which is under phase III clinical investigation in relapsed multiple myeloma. Immunogen The details of the immunogen for this antibody are not available. Host Species Mouse Derivation Humanized (from mouse) Type IgG1 – kappa Species Reactivity Human Applications Suitable…
Recombinant Humanized (from mouse) antibody to Human MUC1. Host Species Mouse Derivation Humanized (from mouse) Type IgG1 Specificity MUC1 (mucin 1, polymorphic epithelial mucin, PEM, episialin, CD227) [Homo sapiens] Species Reactivity Human Applications Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods. CAS 372075-37-1 Generic Name sontuzumab Related…
Recombinant humanized (from mouse) antibody expressed in CHO binding to human SELL/CD62L. Aselizumab is an immunosuppressive drug which has been investigated for the use in severely injured patients. Immunogen The details of the immunogen for this antibody are not available. Host Species Mouse Derivation Humanized (from mouse) Type IgG4 Species Reactivity Human Applications Suitable for…
Recombinant monoclonal antibody to CD18. Rovelizumab, also known as LeukArrest and Hu23F2G, is a humanized monoclonal antibody which was an experimental immunosuppressive drug. The drug is a monoclonal antibody that suppresses white blood cells which become overly active during shock. Immunogen The details of the immunogen for this antibody are not available. Host Species Mouse…
Antibodies, the extraordinary proteins that serve as the frontline troops of the human immune system, have recently gained attention for their ability to combat tiny compounds known as haptens. Because of their small size, these elusive targets present particular difficulty for the immune system to identify as foreign invaders. However, researchers’ inventiveness has resulted in…
Therapeutics based on macromolecular proteins and peptides have successfully been efficiently applied to treat serious human diseases. With the development of biotechnologies, a great number of authorized protein therapeutics and drug products have been utilized in clinical research over the last few decades. However, the main issue that needs to be resolved currently for protein therapeutics is the short half-lives caused by fast degradation…
Therapeutics that block inhibitory checkpoints or activate stimulatory checkpoints have proven to be effective in restoring anti-tumor immune responses and treating cancer in recent years. In particular, the FDA-approved drugs targeting immune checkpoints like cytotoxic T-lymphocyte antigen (CTLA-4), programmed cell death (PD-1), and its ligand (PD-L1) to treat various types of cancers have revolutionized the field of oncology. With…
As an expert in providing solutions to assist virology and microbiology research, Creative Diagnostics announced the launch of its new Antimicrobial Susceptibility Testing (AST) services. These services are designed to help biotechnology and pharmaceutical researchers detect the sensitivity of test bacteria to antimicrobial drugs. Antimicrobial susceptibility testing is a laboratory procedure that is primarily used…
Creative Diagnostics, a leading manufacturer and supplier of antibodies, antigens and assay kits, has announced a series of new reagent solutions to assist researchers in the bioanalysis of antibody-drug conjugates (ADCs), including ELISA kits, anti-drug antibodies, anti-MMAE antibodies and paired conjugates. ADCs are a class of conjugated monoclonal antibodies that covalently bind cytotoxic small-molecule compounds…
CD BioSciences, a US-based biotechnology company focusing on the development of imaging technology, introduced its new services based on super-resolution imaging technology to assist researchers in studying various cellular activities in cellular structures, such as DNA/RNA and protein interactions, DNA replication and transcription, vesicle motility, and bacterial transcription. Microscopes are the most common research tools…
CD BioSciences, a US-based CRO serving the global life science research community, has announced a series of new solutions on mitotic catastrophe, including Regulator Identification, Chemical Screening, Regulator Characterization, Cell Death Characterization, and Animal Model Generation. Mitotic catastrophe is an irreversible arrest of the cell cycle that occurs when chromosomes undergo severe aberrations or the…
STEMart, a US-based provider of comprehensive services for all phases of medical device development, recently announced the launch of new Ethylene Oxide Sterilant Residual Testing services. The new services will help manufacturers and healthcare providers ensure the safety of EO-sterilized medical devices by determining accepted residual limits. Ethylene oxide (EO) is a colorless gas that…
siRNA is one of the valued tools which is widely used to investigate the functions of genes and gene silencing. However, poor stability, immunogenic and off-target effects make siRNA is not optimal drug-like molecule. Custom chemically-modified siRNA overcomes these challenges, chemical modifications of siRNA therapeutics significantly improve their pharmacological and therapeutic properties. There are three kinds of…
Recent years witness the continuous clinical feasibility and increasing commercial value of antibody-drug conjugates (ADCs). As a result, many research institutions attempt to connect PROTAC with monoclonal antibody (mAb) by imitating the design principle of ADC to improve the delivery efficiency of PROTAC in vivo. This combination is called degrader-antibody conjugates (DACs), which can overcome the…
In general, there are two types of culture systems for directed neural differentiation of hESC, including adherent and suspension culture. In a prolonged culture, an embryoid body (EB) can form a multilayered structure and cavities filled with cystic fluid. In addition, a variety of signaling molecules, factors, and conditioned media have been used for directed…
CNS drug discovery has been hampered by inadequate understanding or consideration of a number of factors. These include the complexity of brain anatomy and function; the neuro-PK with regard to the blood-brain barrier (BBB) transport and intra-brain distribution as well as the measures to study these processes; adequate biomarkers of CNS drug effects (neuro-PD), and…
Equipped with our advanced phage display platform, hybridoma platform, as well as other advanced antibody development platforms, we can provide a full range of neuronal marker antibody production services. From gene synthesis to antibody purification and labeling, we can produce antibodies in both research and diagnostic applications. Creative Biolabs is one of the well-recognized experts who…
It is increasingly recognized that Bacteroides dorei (B. dorei) plays a pivotal role in the development of several kinds of diseases such as cardiovascular disease and metabolic disease. Creative Biolabs has rich experience in developing and producing live biotherapeutic products, with both aerobic and anaerobic organisms. We now provide customized B. dorei-based drug discovery services and products for global clients….
Bifidobacterium bifidum (B. bifidum) usually represent the most abundant bacteria in the human intestinal flora of healthy breast-fed infants. It shows significant physiological and genetic characteristics, including adhesion to the epithelium and the metabolism of host-derived glycans. Taking advantage of the specific adaptability of B. bifidum to human intestines and its significance in supporting host health, Creative Biolabs launched the…
With years of experience in the development of LBPs, Creative Biolabs prides itself on being an innovator and problem solver in LBPs. We offer high-quality potential probiotic strains with award-winning high quality, and perfect customer services that save customers time, money, and stress. When you choose Creative Biolabs as your culture suppler, our experts will guide you…
Live biotherapeutic products are biological products that contain live organisms, such as bacteria, that are naturally occurring, recombinant, or clonally selected and can be used in the prevention, treatment, or cure of a disease/condition. Microbial identification for live biotherapeutic products has been based on many different techniques that provide a faster, more accurate identification and…
Characterization of plasmids or nucleic acid constructs is fundamental to the development of gene therapy approaches. We are committed to providing automated and highly sensitive analytical methods to fully measure and characterize nucleic acids and plasmids, which are essential for the discovery and manufacture of gene therapies for rare diseases. Our transferable and reproducible workflows can…
The goal was to develop a platform that could program comprehensive biosynthesis development in one place, and since then, it has become a reality. The Synthetic Biology Platform is a disruptive technology platform focusing on synthetic biology, which can contribute to the advancement of diverse areas, including but not limited to industrial biotechnology, pharmaceutical, agriculture,…
Equipped with professional technical scientists, powerful platforms, and abundant experience, Creative Biolabs provides comprehensive immune checkpoint functional assays to facilitate our clients’ meaningful immunotherapy project development. We offer high-quality custom services by adjusting strategies to meet particular requirements. Immune checkpoints maintain self-tolerance and help to avoid collateral damage during a physiological immune response. Studies have shown that…
The immune checkpoint inhibitors perform their functions through blocking interactions between immune checkpoint protein and ligand. Creative Biolabs has accumulated rich experience in immune checkpoint assays development for many years. Armed with our established technology platform, we can offer a full range of immune checkpoint binding and interaction assays to support your drug development project.
With our world-leading technology platforms and professional experts in antibody development, Creative Biolabs has perfected our technical pipelines in immune checkpoint antibody development. Our comprehensive service portfolio includes polyclonal antibody discovery and development, monoclonal antibody (mAb) discovery and development, antibody fragment discovery and development, antibody characterization, antibody engineering and optimization, antibody production, and manufacture. We will…
Macrophages are specialized cells that rapidly recognize, engulf, and destroy pathogens or apoptotic cells. One of the fundamental features of macrophages is their high plasticity, which allows them to respond to stimuli from the complex tissue microenvironment, by changing rapidly their functional profile through polarization. Macrophages reveal specific phenotypes and functions in response to different…
Macrophages commonly exist in two distinct subsets: classically activated macrophages (M1) and alternatively activated macrophages (M2). M1 macrophages can facilitate immunity to remove foreign pathogens and tumor cells, mediate tissue damage, and impair wound healing and tissue regeneration. A better understanding of the molecular pathways and transcriptional programs associated with M1 macrophage subtypes, as well…
