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The ability of Polyethylene glycol (PEG) to influence the pharmacokinetic properties of drugs and drug carriers is currently utilized in a wide variety of established and emerging applications. The change in the pharmacokinetics of administered drugs by being shielded by or bound to PEG results in prolonged blood circulation times. This consequently increases the probability…
Cyclic amino acids are a class of amino acids that contain a cyclic structure in their side chain. These amino acids typically have a different structure compared to the standard amino acids found in proteins. One example of a cyclic amino acid is proline, which has a five-membered ring structure in its side chain. Proline…
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Lipid nanoparticles (LNPs) are novel spherical vesicles with core-shell nanostructure. A typical LNP usually has a specially designed ionizable lipid component, which is positively charged at low pH (for RNA complexation) and neutral at physiological pH (reducing potential toxic effects compared with cationic liposomes). Due to their special characteristics and small size (~100 nm), LNPs…
Liposomes are spherical vesicles synthesized from cholesterol, non-toxic surfactants, sphingolipids, glycolipids, long-chain fatty acids, and even membrane proteins. Almost since the discovery and proving of its encapsulation potential in the 1960s, liposomal vesicles, as potential carriers of a variety of biologically active molecules, have a broad application prospect in the treatment of humans and animals….
Liposomes have received attention not only because of their use as a model membrane system, but also for drug delivery. As a drug delivery system, liposomes have significant therapeutic advantages in the targeting and controlled release of active ingredients. Introduction of Liposomal Formulation Liposomes are an ideal drug delivery system because they are similar in…
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Aptamers, like antibodies, can specifically bind to targets and modulate or block their activity. An in vitro selection process from pools of random sequence oligonucleotides has generated aptamers for over 100 proteins including growth factors, transcription factors, enzymes, and immunoglobulins. With years of ample experience in antibody drug development, our scientists are confident in providing a…
Complement activation can be assessed by measurement of complement activation products, which reflect the stimulation of any of the activating pathways. Creative Biolabs is one of the world’s largest suppliers of complement testing, providing customers with high-quality complement activation product test services from diagnostics to drug development.
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If we accept that Mayfield is always likely to be the starter that’s where things get interesting. The Panthers recruited Ben McAdoo, who was slated to be the new head coach of the offense. In the beginning, it was a baffling decision that looked like it was bound to face similar issues as during the…
What is Morris Water Maze Test? The Morris water maze is a test based on the habit of mice that are averse to being in water and are forced to swim to find a platform hidden in the water, and is widely used in cognitive memory tests to determine spatial location and orientation in rodents….
In the field of scientific research, understanding and studying emotion-related behaviors in animals plays a crucial role in advancing the knowledge of the human brain and mental health. Animal models can help researchers better comprehend animal behaviors, and rodent models in particular have become important objects for understanding the mechanisms of emotional behaviors and exploring new treatments…
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